The RAG proteins and V(D)J recombination: complexes, ends, and transposition.

By S. Fugmann, A. Lee, P. Shockett, I. Villey, D. Schatz. Annual Review of Immunology, 2000

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Mechanisms of chromosomal translocations in B cell lymphomas (2001, background): “…of the reaction is catalyzed, in addition to the RAG proteins, by enzymes that are also involved in non-homologous double-strand DNA break repair, including DNA±PK (which is composed of the DNA-PK catalytic subunit and the Ku70 and Ku80 proteins), DNA ligase IV and XRCC4 (Fugmann et al., 2000).”
Unraveling V(D)J Recombination: Insights into Gene Regulation (2004, neutral): “…of particular combinations of V, D, and Jrelied on soluble truncated “core” versions of RAG-1 and RAG-2 that are active in the cleavage/joining reaction segments may be restricted in a manner not explained by simple 12/23 compatibility (Lieber et al., 1994; Feeney(Figure 4A; Fugmann et al., 2000).”
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells (2003, neutral): “V(D)J recombination assembles the gene segments that comprise the exon encoding the antigen receptor–binding pockets for immunoglobulins and T cell receptor”