Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

By Xiaoming Hu, Peiying Li, Yanling Guo, Haiying Wang, R. Leak, Songela Chen, Yanqin Gao, Jun Chen. Stroke, 2012

1,413 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1775d87c34e0245a02b7427b3e792ce7961c0d6b

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In Immunology

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Citations in the corpus

Immune responses to stroke: mechanisms, modulation, and therapeutic potential. (2020, background): “Early studies on the immune alternative activation, including Arg1, YM1 (Chil3), and CD206 (Mrc1) (74), consistent with a protective role.”
Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro (2013, methodology): “However, the presence of an early M2 phenotype (preceding M1) has recently been reported after hypoxic/ischemic injury in vivo (Hu et al., 2012).”
Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “…majority of microglia and recruited macrophages at the site of injury have mixed M1- and M2-like activation profiles, but that the M2-like response is short-lived and there is a phenotypic shift towards an M1-like dominant response within one week of injury (Hu et al., 2012; Kigerl et al., 2009).”
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “Even though the proinflammatory response is dominant, there does appear to be an anti-inflammatory signal that attempts to regulate the inflammation [78].”
Neuroinflammation in Parkinson’s disease and its potential as therapeutic target (2015, background): “however, gradually become predominant in later stages [32].”
Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “…David and Kroner (2011), Harms et al. (2013) iNOS Metabolic enzyme Synthesis of nitric oxide from arginine Yes Yes Yes Yes David and Kroner (2011), Hu et al. (2012) COX2 Metabolic enzyme Prostaglandin synthesis Yes Yes Yes Yes Chhor et al. (2013), David and Kroner (2011) CCL, chemokine (C-C…”
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “…phenotypes are found in different patters from the core of the ischemic zone to the penumbra (Perego et al., 2011), and the local microglia and newly recruited macrophages with the M2 phenotype were gradually transformed into the M1 phenotype in the peri-infarct regions over time (Hu et al., 2012).”
Inflammation and Stroke: An Overview (2016, background): “In addition, depending on molecular cues encountered in the postischemic brain parenchyma, MMΦ can undergo classical (M1, proinflammatory) or alternative (M2, anti-inflammatory in most settings) activation, thus contributing to the resolution of inflammation [51, 52].”
The biphasic function of microglia in ischemic stroke (2017, positive): “Conditioned medium from M2 phenotype reduced neuronal death in brain slices under OGD condition.”