Abstract 10466: In Vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes

By Li Qian, Yu Huang, A. Foley, V. Vedantham, Ian Spencer, Simon J. Conway, Ji-Dong Fu, Deepak Srivastava. Circulation, 2011

1,291 citations recorded by the source corpus.

<jats:p> <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="Li_Qian.gif" /> </jats:p> <jats:p>Li Qian, 2011 Finalist and Presenting Author</jats:p>

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/176e2b8dedbad7a17c7e6279762cdeb0f2cd34ac

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Citations in the corpus

Engineering Adolescence: Maturation of Human Pluripotent Stem Cell-derived Cardiomyocytes (2014, background): “When reprogramming was performed in vivo,(112,115) however, the induced cardiomyocytes displayed morphological and functional properties of adult cardiomyocytes with elongated cell shape, intercalated disks with polarized connexin 43 expression, and electrophysiological parameters similar to the adu”
Hippo pathway effector Yap promotes cardiac regeneration (2013, neutral): “Proc Natl Acad Sci USA 104(5):1631–1636.”
Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage (2012, neutral): “These insights will be valuable to develop improved cardiac reprogramming strategies (Ieda et al., 2010; Qian et al., 2012; Song et al., 2012; Takeuchi and Bruneau, 2009) and to elucidate how disruption of these diverse regulatory modules contributes to congenital heart disease.”
Regenerative medicine: Current therapies and future directions (2015, background): “Direct reprogramming in vivo by retroviral injection has been reported to result in greater efficiency of conversion, compared with ex vivo manipulation, and allows in vitro culture and transplantation to be bypassed (130).”
Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications (2019, background): “An alternative approach would be the direct conversion of somatic cells such as fibroblasts into clinically relevant phenotypic cells such as neurons and cardiomyocytes to preserve the cellular ageing markers and possibly maturation state [111,112].”
Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration (2016, background): “ture cardiomyocytes and seem to make connections to endogenous cardiomyocytes (Song et al. 2012; Qian et al. 2012; Ma et al. 2015).”