Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2
By H. Hirai, Kazuya Tanaka, O. Yoshie, K. Ogawa, K. Kenmotsu, Y. Takamori, M. Ichimasa, K. Sugamura, Masataka Nakamura, S. Takano and 1 more. Journal of Experimental Medicine, 2001
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Prostaglandin (PG)D2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions of PGD2 cannot be explained by DP alone. We show here that a seven-transmembrane receptor, CRTH2, which is preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils in humans, serves as the novel receptor for PGD2. In response to PGD2, CRTH2 induces intracellular Ca2+ mobilization and chemotaxis in Th2 cells in a Gαi-dependent manner. In addition, CRTH2, but not DP, mediates PGD2-dependent cell migration of blood eosinophils and basophils. Thus, PGD2 is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2.
Subfields: Genetics, Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/176518d87ec591b60211f0cfaaa7feacda0f8e31
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Citations in the corpus
- Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. (2004, background): “Similar to many chemoattractant receptors, the CRTH2 receptor couples to a Gi-type G protein leading to inhibition of cAMP and increases in intracellular calcium in a variety of cell types (Hirai et al., 2001; Sawyer et al., 2002).”
- Eosinophils: Biological Properties and Role in Health and Disease (2008, background): “Interestingly, the PGE2 receptor is also expressed by basophils and Th2 cells (and is now designated ‘‘chemoattractant receptor Th2 cells’’ or CRTH2) and appears to comediate Th2 cell and eosinophil/basophil recruitment (Hirai et al. 2001).”
- Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. (2001, background): “PGD2 acts through two receptors, the DP receptor and the recently identified CRTH2 receptor (chemoattractant receptorhomologous molecule expressed on Th2) (8).”