Role of the microbiome in human development
By M. Dominguez-Bello, F. Godoy-Vitorino, Rob Knight, Martin J. Blaser. Gut, 2019
648 citations recorded by the source corpus.
The host-microbiome supraorganism appears to have coevolved and the unperturbed microbial component of the dyad renders host health sustainable. This coevolution has likely shaped evolving phenotypes in all life forms on this predominantly microbial planet. The microbiota seems to exert effects on the next generation from gestation, via maternal microbiota and immune responses. The microbiota ecosystems develop, restricted to their epithelial niches by the host immune system, concomitantly with the host chronological development, providing early modulation of physiological host development and functions for nutrition, immunity and resistance to pathogens at all ages. Here, we review the role of the microbiome in human development, including evolutionary considerations, and the maternal/fetal relationships, contributions to nutrition and growth. We also discuss what constitutes a healthy microbiota, how antimicrobial modern practices are impacting the human microbiota, the associations between microbiota perturbations, host responses and diseases rocketing in urban societies and potential for future restoration.
Subfields: Molecular Biology, Speech and Hearing
View Paper: https://www.semanticscholar.org/paper/1734670e402403b35d226acfdee7618dd0747b96
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Citations in the corpus
- Microbiome definition re-visited: old concepts and new challenges (2020, background): “[16] suggest that changes in the human microbiota occurring concomitantly with industrialization may be the underlying factor dramatic increases in metabolic, immune, and cognitive diseases, including obesity, diabetes, asthma, allergies, inflammatory bowel disease, and autism in the “developed” wor”
- Bifidobacteria-mediated immune system imprinting early in life (2020, background): “Dysbiosis of the infant gut microbiome is common in modern societies and a likely contributing factor to the increased incidences of immune-mediated disorders (Dominguez-Bello et al., 2019; Mohammadkhah et al., 2018; Sonnenburg and Sonnenburg, 2019).”