Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor.

By A. Samuelsson, Terri L. Towers, J. Ravetch. Science, 2001

1,080 citations recorded by the source corpus.

Subfields: Hematology, Immunology and Allergy, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/171341ac76fb7eb66384412eab7b373d4b371e6e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. J. Ravetch

In Immunology and Allergy

1. J. Ravetch
2. S. Galli

In Radiology, Nuclear Medicine and Imaging

1. S. Galli
2. J. Ravetch
3. F. Nimmerjahn

Citations in the corpus

• FcRn: the neonatal Fc receptor comes of age (2007, background): “High-dose intravenous immunoglobulin (IVIG) treatment is thought to exert an immunomodulatory effect by numerous mechanisms, including engagement of the inhibitory FcγRIIb recepto”
• Protein aggregation diseases: pathogenicity and therapeutic perspectives (2010, background): “Although the mechanism of action remains unclear, these studies raise the interesting question of whether immunotherapy for Alzheimer's disease needs to be directed against the Aβ peptide, or whether general immunomodulation (possibly through Fcγ-mediated engulfment of amyloid deposits by microglia,”
• IgG Placental Transfer in Healthy and Pathological Pregnancies (2011, background): “High-dose IVIG treatment is thought to exert an immunomodulatory effect by numerous mechanisms, including engagement of the inhibitory FcγRIIb receptor [118] and by FcRn saturation [117].”
• Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway (2011, background): “, and increase the threshold for activation by pathogenic immune complexes, consistent with the FcgRIIB requirement of IVI”
• Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis (2002, background): “Intravenous immunoglobulins may act via targeting the inhibitory receptor FcγRIIb (ref”
• Antibody-based therapies for malaria (2005, background): “For example, antibodies can be effective in controlling malaria by reducing the damage that results from excessive host inflammatory response”
• Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. (2006, background): “The mechanism of action is believed to be mediated by immunomodulatory capacity exerted by Fc receptor blockade and potentially through ligation of inhibitory Fc receptors.(63) Importantly, high-dose IGIV has been compared with systemic corticosteroids in randomized multicenter trials and was found ”