Toxicity of cationic lipids and cationic polymers in gene delivery.

By Hongtao Lv, Shubiao Zhang, B. Wang, S. Cui, Jie Yan. Journal of Controlled Release, 2006

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Advances and Challenges of Liposome Assisted Drug Delivery (2015, background): “Inclusion of a heterocyclic ring has been shown to spread the positive charge of the head-group, thus attenuating the toxicity level (Lv et al., 2006).”
Knocking down barriers: advances in siRNA delivery (2009, background): “Toxicity of certain cationic lipid particles has been reported both in vitro and in vivo [76] [77] [78] , and certain synthetic agents have been found to induce a gene signature of their own that might increase the off-target effects of siRNA 79, 80 .”
Brief update on endocytosis of nanomedicines (2019, background): “However, in this case, efficacy would have to be balanced with cytotoxicity arising from exposure to a high concentration of cationic materials [117,118].”
Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. (2011, background): “Typical approaches to increase the efficacy of CpG ODNs include chemical modification of ODNs for resistance of enzymatic degradation(36,37) and complexation of ODNs with cationic polymers or lipids for efficient cellular uptake,(38) 40 which nevertheless raise potential safety concerns.(41,42) In a”