Management of COVID-19 Respiratory Distress.
By J. Marini, L. Gattinoni. Journal of the American Medical Association (JAMA), 2020
1,020 citations recorded by the source corpus.
Acute respiratory distress syndrome (ARDS) can originate from either the gas or vascular side of the alveolus. Although the portal for coronavirus disease 2019 (COVID-19) is inhalational, and alveolar infiltrates are commonly found on chest x-ray or computed tomography (CT) scan, the respiratory distress appears to include an important vascular insult that potentially mandates a different treatment approach than customarily applied for ARDS. Indeed, the wide variation in mortality rates across different intensive care units raises the possibility that the approach to ventilatory management could be contributing to outcome.1-3 COVID-19 is a systemic disease that primarily injures the vascular endothelium. If not expertly and individually managed with consideration of the vasocentric features, a COVID-19 patient with ARDS (“CARDS”) may eventually develop multiorgan failure, even when not of advanced age or predisposed by preexisting comorbidity.
Subfields: Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/16f14d86314b3ee2af7685929f0c21d375076a39
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In Pulmonary and Respiratory Medicine
Citations in the corpus
- How and why patients made Long Covid (2020, neutral): “Definitions of COVID-19 itself remain unstable: the pathology has been defined as a respiratory, cardiovascular, endothelial, or systemic condition (Lescure et al., 2020; Marini and Gattinoni, 2020).”
- Risk and Financial Management of COVID-19 in Business, Economics and Finance (2020, background): “In an illuminating and instructive paper, Marini and Gattinoni (2020) evaluated the careful ventilatory workload management of the vasocentric features of COVID-19, the failure of which may lead to multiorgan deterioration and ultimate failure.”
- Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy. (2020, neutral): “Length of hospital stay, median (IQR), d 22 (12-42) 12 (8-19) 39 (24-61) 79 (74-84) <.”
- Federated learning for predicting clinical outcomes in patients with COVID-19 (2021, background): “There is wide variation in the clinical course of patients who present to hospital with symptoms of COVID-19, with some experiencing rapid deterioration in respiratory function requiring different interventions to prevent or mitigate hypoxemia 62,63 .”