A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
By Allen Y. Chen, Y. Chen. Food Chemistry, 2012
903 citations recorded by the source corpus.
Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary kaempferol in reducing the risk of chronic diseases, especially cancer. Epidemiological studies have shown an inverse relationship between kaempferol intake and cancer. Kaempferol may help by augmenting the body’s antioxidant defense against free radicals, which promote the development of cancer. At the molecular level, kaempferol has been reported to modulate a number of key elements in cellular signal transduction pathways linked to apoptosis, angiogenesis, inflammation, and metastasis. Significantly, kaempferol inhibits cancer cell growth and angiognesis and induces cancer cell apoptosis, but on the other hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect. The aim of this review is to synthesize information concerning the extraction of kaempferol, as well as to provide insights into the molecular basis of its potential chemo-preventative activities, with an emphasis on its ability to control intracellular signaling cascades that regulate the aforementioned processes. Chemoprevention using nanotechnology to improve the bioavailability of kaempferol is also discussed.
Subfields: Cancer Research, Computational Theory and Mathematics, Oncology
View Paper: https://www.semanticscholar.org/paper/16de319f3916e38f8d4f9863b72b50c756ae6ea6
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Citations in the corpus
- Flavonoids in Cancer and Apoptosis (2018, background): “Kaempferol or 3,4,5,7-tetrahydroxyflavone is a nontoxic dietary flavonoid distributed in tea, kale, beans, onions, tomatoes, strawberries, broccoli, cabbage, apples, and grapes [71,72].”
- Polyphenols: A concise overview on the chemistry, occurrence, and human health (2019, neutral): “…& Burman, 2009; L. Li, Zhang, & Du, 2018; Miltonprabu et al., 2017; Oboh, Ademosun, & Ogunsuyi, 2016; Rauf et al., 2018), and (Calderón‐Montaño, Burgos‐Morón, Pérez‐Guerrero, & López‐Lázaro, 2011; A. Y. Chen & Chen, 2013; Devi et al., 2015; Imran et al., 2019) against several chronic diseases.”
- Important Flavonoids and Their Role as a Therapeutic Agent (2020, background): “It stimulates the body’s antioxidants against free radicals that cause cancer [36].”
- Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels (2019, background): “(STZ)-induced diabetic rats High fat di t m e Pancreatic βcells [90,91]”