Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes.

By D. Ryan, Mark A. Espeland, G. Foster, S. Haffner, V. Hubbard, K. Johnson, S. Kahn, W. Knowler, S. Yanovski. Controlled Clinical Trials, 2003

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Introduction to SMART designs for the development of adaptive interventions: with application to weight loss research (2014, background): “Despite the general success of interventions such as IBT (and others [7, 10–14]), a significant number of individuals do not lose a clinically significant amount of weight (for example, ≥7 % weight loss in a 26week period (~6 months) [15]) or meet their targeted goals for weight loss.”
Eight-Year Weight Losses with an Intensive Lifestyle Intervention: The Look AHEAD Study (2014, neutral): “In year 1, ILI participants received a comprehensive lifestyle intervention designed to induce an average, study-wide loss 7% of initial weight (with an individual goal of losing 10%) (1,19).”
Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease. (2005, background): “An ongoing large-scale trial, the Look AHEAD (Action for Health in Diabetes) study funded by the National Institute of Diabetes and Digestive and Kidney Diseases, should provide additional information about the long-term ( 10 yr) effects of sustained weight loss through exercise and decreased calori”
A randomized controlled trial of financial incentives for weight loss (2008, background): “duction after age 70 years is relatively weaker than at younger ages.(7) We chose an upper limit on a BMI of 40 to minimize the influence of outliers on the main result of weight loss.”