E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.

By F. Petrocca, R. Visone, Mariadele Rapazzotti Onelli, M. Shah, M. Nicoloso, Ivana de Martino, D. Iliopoulos, E. Pilozzi, Chang-Gong Liu, M. Negrini and 7 more. Cancer Cell, 2008

902 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/16a257652515edc383ec4cd22f3f8c6e2d7c51e1

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Citations in the corpus

miR-24 inhibits cell proliferation by suppressing expression of E2F2, MYC and other cell cycle regulatory genes by binding to “seedless” 3′UTR microRNA recognition elements (2009, background): “For instance, the miR-17 92 cluster directly downregulates the E2F family (O’Donnell et al., 2005; Petrocca et al., 2008).”
microRNAs in cancer (2013, background): “(134) demonstrated that the miR-106b/25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7.”
MicroRNA control in the immune system: basic principles. (2009, background): “…PI3K pathway (Xiao et al., 2008), and a few critical cell cycle regulators (such as p21, Rbl2, E2F1, E2F2, and E2F3), as suggested by studies in various cellular contexts (Lu et al., 2007; O'Donnell et al., 2005; Petrocca et al., 2008; Sylvestre et al., 2007; Wang et al., 2008) (Figure 4C).”
Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, background): “Such a mechanism has also been established for the regulation of p21/WAF1 by miR-106b in human colon and gastric cancer cells (13, 14).”
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer (2010, background): “, 2005), and mir-106b-25 can block TGF-b-mediated growth arrest in gastric cancers by targeting p21/CIP1 and the proapoptotic protein BIM (Figure 3a; Petrocca et al., 2008).”
miRiad roles for the miR-17-92 cluster in development and disease. (2008, background): “A cluster of papers in Cell and Nature Immunology as well as Cancer Cell have also identified the proapoptotic gene BCL2L11/BIM as a direct target of multiple members of the miR-17-92 cluster and related miRNAs (Koralov et al., 2008; Petrocca et al., 2008; Ventura et al., 2008; Xiao et al., 2008).”
The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. (2009, background): “In gastric tumors, this cluster negatively regulated TGFβ tumor suppressor activities [24].”