The role of short-chain fatty acids in health and disease.

By Jian Tan, Craig I. McKenzie, M. Potamitis, A. Thorburn, C. Mackay, L. Macia. Advances in Immunology, 2014

2,003 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/1695fcca49c7a9c8b6c19d9e1ae759b8e1ed3272

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In Molecular Biology

1. Zahraa Al Bander
2. Guolong Zhang
3. N. Naderpoor
4. Aya Mousa
5. M. Nitert

Citations in the corpus

• Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation (2014, neutral): “ity in regulating intestinal inflammation (54).”
• Pathophysiology of Type 2 Diabetes Mellitus (2020, background): “Furthermore, intestinal dysbiosis can reduce short-chain fatty acid synthesis that promotes gut barrier integrity, pancreatic β-cell proliferation and insulin biosynthesis [78,79].”
• Short- and medium-chain fatty acids in energy metabolism: the cellular perspective (2016, background): “In humans, the major source of SCFAs is the fermentation of dietary fiber and undigested saccharides in the gut by colonic anaerobic bacteria (2) [reviewed in (3, 4, 7)].”
• Butyrate: A Double-Edged Sword for Health? (2018, background): “Two SCFA transporters exist, including monocarboxylate transporter (MCT) isoform 1 (MCT1), which is coupled to a transmembrane H+-gradient (28), and solute carrier (SLC) family 5 member 8 (SLC5A8), which is also known as sodium-coupledmonocarboxylate transporter (SMCT) 1 (SMCT1) and is a Na+-coupled”
• The role of short-chain fatty acids in immunity, inflammation and metabolism (2020, background): “The role of gut microbiome in host health is mainly mediated by the metabolites of short-chain fatty acids (SCFAs) which are the main metabolites produced by specific gut microbiome fermenting resistant starch and dietary fiber (Tan et al. 2014).”
• Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis (2020, background): “are regulated by the diet, and given their importance in their immunomodulatory functions, their intake has been very much discussed in relation to inflammatory diseases in Westernized countries [163,164].”
• Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances (2016, background): “…players in the maintenance of gut physiology and integrity, Frontiers in Microbiology | www.frontiersin.org 4 January 2016 | Volume 6 | Article 1543 promote immune andmetabolic homeostasis and have important anti-inflammatory and antitumorigenic effects (Bindels et al., 2012; Tan et al., 2014).”
• The Gut Microbiota and Inflammation: An Overview (2020, background): “Certain species of microbes produce specific enzymes that enable fermentation of nutrients into absorbable forms, including that of indigestible carbohydrates into short-chain fatty acids (SCFAs) [62,63].”