Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

By Shayna E. A. Street, E. Cretney, M. Smyth. Blood, 2001

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Type I interferon is selectively required by dendritic cells for immune rejection of tumors (2011, positive): “…studies supporting the existence of cancer immunoediting revealed an important function for IFN  in suppressing tumor de velopment in models of both tumor transplan tation and primary tumor induction (Dighe et al., 1994; Kaplan et al., 1998; Shankaran et al., 2001; Street et al., 2001, 2002).”
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion (2018, background): “In addition, C57BL/6 mice that lack the gene encoding IFN-γ also displayed higher susceptibility to experimental (B6, RM-1 prostate carcinoma) and spontaneous (BALB/c, DA3 mammary carcinoma) models of primary and metastatic tumors (13, 14).”
New aspects of natural-killer-cell surveillance and therapy of cancer (2002, background): “, recent evidence indicates that NK-cell IFN-γ also contributes to effector functions against tumour metastases and sarcoma induction by MC”
Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice1 (2002, background): “We also demonstrated that IFN-mediated TRAIL induction on NK cells plays some role in IFN-dependent antimetastatic effects of IL-12 and -galactosylceramide ( -GalCer) (14).”