“Engineering Substrate Micro- and Nanotopography to Control Cell Function”
By C. Bettinger, Robert Langer, J. Borenstein. Angewandte Chemie, 2009
1,215 citations recorded by the source corpus.
Lead-In The interaction of mammalian cells with nanoscale topography has proven to be an important signaling modality in controlling cell function. Naturally occurring nanotopographic structures within the extracellular matrix present surrounding cells with mechanotransductive cues that influence local migration, cell polarization, and other functions. Synthetically nanofabricated topography can also influence cell morphology, alignment, adhesion, migration, proliferation, and cytoskeleton organization. Here we review the use of in vitro synthetic cell-nanotopography interactions to control cell behavior and influence complex cellular processes including stem cell differentiation and tissue organization. Future challenges and opportunities in cell-nanotopography engineering will also be discussed including the elucidation of mechanisms and applications in tissue engineering.
Subfields: Biomedical Engineering, Cell Biology
View Paper: https://www.semanticscholar.org/paper/167ae80354c860cffd342014dc8655652517e4a9
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In Biomedical Engineering
In Cell Biology
Citations in the corpus
- From nanoscopic to macroscopic photo-driven motion in azobenzene-containing materials (2018, neutral): “A large number of works emphasize, indeed, the role of the substrate topographic pattern in influencing cell properties like attachment, spreading and differentiation [212, 213], opening the way to crucial advances in clinical and tissue bioengineering.”
- Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, methodology): “The images in the Figure were adapted with permission from Kilian et al., 2010 (A), Desai et al., 2009 (B), Fu et al., 2010 (C), Bettinger et al., 2009 (E), Teixeira et al., 2003 (F), Gómez-Sjöberg et al., 2007 (G) (Kilian et al., 2010; Desai et al., 2009; Fu et al., 2010; Bettinger et al., 2009;…”
- General functionalization route for cell adhesion on non-wetting surfaces. (2010, background): “Surface properties regulate a variety of intracellular signal cascades for cell proliferation, migration, differentiation, and apoptosis [5,6].”
- Engineering microscale topographies to control the cell–substrate interface (2012, background): “Therefore, many biologists and bioengineers have added microfabrication techniques, used to generate microtopographies, to their armamentarium to study specific cell behaviors [24-28].”