The genetics of the p53 pathway, apoptosis and cancer therapy

By A. Vázquez, E. Bond, Arnold J. Levine, Gareth L. Bond. Nature reviews. Drug discovery, 2008

679 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1633d0d7fabaf45a54758d195cf99c655d424a62

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Johannes Rinn
2. Howard Y. Chang
3. Maite Huarte
4. Eric S. Lander
5. M. Guttman
6. Aviv Regev
7. A. Khalil
8. Or Zuk

In Oncology

1. K. Strebhardt
2. T. Jacks
3. Jay S. Loeffler
4. Eric S. Lander

Citations in the corpus

• A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 response (2010, background): “In particular, we observed a group of lincRNAs that are strongly associated with the p53 transcriptional pathway. p53 is an important tumor suppressor gene involved in maintaining genomic integrity (Vazquez et al., 2008).”
• Charged particles in radiation oncology (2010, background): “In addition, about 50% of cancers harbor mutations in the TP53 gene, which result in a decreased propensity to undergo apoptosis”
• Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (2010, background): “Normal functioning of p53 maintains the stability of the genome and is a potent barrier to cancer developmen”
• How Common are Extra-ribosomal Functions of Ribosomal Proteins? (2009, background): “The identification of MDM2 (and its human ortholog HDM2) as an E3 ligase responsible for the ubiquitination of p53, leading to its rapid degradation (reviewed in Vazquez et al., 2008), suggested a functional role for the interaction of L5 with MDM2.”
• The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “(a) p53—The transcription factor p53 represents a tumour suppressor with well-established functions on genomic integrity, apoptosis and cell cycle control (Vazquez et al., 2008).”
• Epigenetics and Colorectal Cancer (2011, background): “Subsequent to mutations in APC or other genes of the Wnt signaling pathway, mutations in genes such as KRAS or TP53 occur and foster the clonal progression of the polyp cells to cancer”