Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophies

By D. Michele, R. Barresi, M. Kanagawa, F. Saito, R. Cohn, Jakob S. Satz, J. Dollar, I. Nishino, R. Kelley, H. Somer and 4 more. Nature, 2002

793 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/1631d5e18ba4ba7d3e594736f27952831230405e

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In Physiology

A. Varki

Citations in the corpus

Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins (2007, background): “Laminin G domains Abundant evidence indicates that interactions of the G domains of laminins with glycans displayed on α-dystroglycan are important in mediating interactions in the nervous system, at muscle–nerve junctions and in skeletal muscl”
Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome. (2002, background): “The first article (Michele et al. 2002) shows that, in patients with MEB and FCMD, a-dystroglycan is hypoglycosylated and no longer interacts with proteins from the extracellular matrix.”
Physiological roles of aquaporin-4 in brain. (2013, result): “The involvement of the DAPC is also compatible with the observation of a reduced perivascular pool of AQP4 in animals with deficient O-glycosylation of -dystroglycan (104, 162).”
Glycosylation in cellular mechanisms of health and disease. (2006, background): “However, some human muscular dystrophies are due to mutations in laminin as well as in glycosyltransferases operating in the pathway of O-mannose glycan formation on α-dystroglycan (McGowan and Marinkovich, 2000; Yoshida et al., 2001; Michele et al., 2002).”
Cerebellar Synaptic Defects and Abnormal Motor Behavior in Mice Lacking α- and β-Dystrobrevin (2006, background): “…roles, DGC components are present in and required for the proper function of astrocytes whose foot processes directly appose pial and perivascular basal laminas (Ueda et al., 2000b; Neely et al., 2001; Zaccaria et al., 2001; Michele et al., 2002; Moore et al., 2002; AmiryMoghaddam et al., 2003).”