Increase in Circulating Endothelial Progenitor Cells by Statin Therapy in Patients With Stable Coronary Artery Disease

By M. Vasa, S. Fichtlscherer, K. Adler, Alexandra Aicher, H. Martin, A. Zeiher, Stefanie Dimmeler. Circulation, 2001

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Pleiotropic Effects of Statins on the Cardiovascular System (2017, background): “thelial progenitor cells in patients with coronary artery disease within 1 week.(136) This effect is apparently observed only at”
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. (2005, methodology): “These endothelial progenitor cells are positive for endothelial marker proteins such as VEGF receptor 2 (KDR), von Willebrand factor (vWF), VE-cadherin, eNOS, take-up of diacetylated LDL, and bind lectin [5–7].”
Pleiotropic effects of statins. (2005, background): “In patients with stable coronary artery disease, administration of statins for four weeks augmented the number of circulating EPCs and enhanced functional capacity in patients with stable coronary artery disease (75).”
Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target? (2019, background): “Indeed, factors that have been shown to have a positive impact on endothelial function, such as exercise and statins, have also been shown to have a potent positive effect on the mobilization of endothelial progenitor cells [31,32].”
Endothelial dysfunction. (2004, background): “Therapy with statins increases the number of circulating endothelial progenitor cells (146).”