Overview and Findings from the Rush Memory and Aging Project

By David A. Bennett, Julie A. Schneider, Aron S. Buchman, Lisa L. Barnes, Patricia A. Boyle, R. Wilson. Current Alzheimer Research, 2012

830 citations recorded by the source corpus.

The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer's disease (AD). In this manuscript, we first summarize the study design and methods. Then, we present data on: 1) the relation of motor function to cognition, disability, and death; 2) the relation of risk factors to cognitive and motor outcomes, disability and death; 3) the relation of neuropathologic indices to cognitive outcomes; 4) the relation of risk factors to neuropathologic indices; and 5) additional study findings. The findings are discussed and contextualized.

Subfields: Cognitive Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/15c4a8e736b3c1740abf545b745040d5b9968aea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Julie A. Schneider

In Physiology

1. Andrea A. Baccarelli
2. Luigi Ferrucci
3. A. Lu
4. A. Reiner
5. Themistocles L. Assimes
6. Lifang Hou
7. M. Levine
8. J. Stewart

In Psychiatry and Mental health

1. Julie A. Schneider
2. David A. Bennett

Citations in the corpus

• MIND diet slows cognitive decline with aging (2015, methodology): “Details of the MAP study were published previously [14].”
• MIND Diet Associated with Reduced Incidence of Alzheimer’s Disease (2015, methodology): “The ongoing open cohort study began in 1997 and includes annual clinical neurological examinations as previously described [6].”
• Impact of multiple pathologies on the threshold for clinically overt dementia (2017, methodology): “Here we update the prevalence and proportions of mixed pathologies we have gathered from the ROS/ MAP studies (general information on these communitybased cohorts and clinical and pathologic diagnoses can be found in [12, 13].”
• Religious Orders Study and Rush Memory and Aging Project (2018, neutral): “The last review of these studies summarized findings through the end of 2011 [10, 11].”
• An epigenetic biomarker of aging for lifespan and healthspan (2018, methodology): “DNAm PhenoAge measured in dorsolateral prefrontal cortex relates to Alzheimer’s disease and related neuropathologies Using postmortem data from the Religious Order Study (ROS) and the Memory and Aging Project (MAP), we find a moderate/high correlation between chronological age and DNAm PhenoAge (pan”