Receptor-Specific Signaling for Both the Alternative and the Canonical NF-κB Activation Pathways by NF-κB-Inducing Kinase

By P. Ramakrishnan, Wangxia Wang, D. Wallach. 2004

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. (2007, background): “However, NIK is required for the activation of the classical NF-kB pathway by certain TNF receptor family members, including CD40 (Ramakrishnan et al., 2004).”
Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009, background): “It should also be noted that NIK is required for the activation of both the classical and alternative NF-κB pathways in response to CD40L and BAFF in Burkitt lymphoma-derived lymphoblastoid cell”