Detecting Awareness in the Vegetative State

By Adrian M. Owen, M. Coleman, Melanie Boly, Matthew H. Davis, Steven Laureys, J. Pickard. Science, 2006

929 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Epidemiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/1567850e94be50e52ced802172af4ebde0111261

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Stanislas Dehaene
2. Vinod Menon
3. Olaf Sporns
4. Giulio Tononi
5. Michael D. Greicius
6. Melanie Boly
7. Srikanth Ryali
8. Andrea Kübler

In Epidemiology

1. Claude-Alain Hauert
2. Patrik Vuilleumier
3. Steven Laureys
4. V. Verdon
5. K. Lovblad
6. Sophie Schwartz

In Psychiatry and Mental health

1. Vinod Menon
2. Giulio Tononi
3. Audrey Vanhaudenhuyse
4. Melanie Boly
5. Steven Laureys
6. Michael D. Greicius

Citations in the corpus

• A Theoretically Based Index of Consciousness Independent of Sensory Processing and Behavior (2013, background): “PCI should also be validated in selected patients who are clinically VS but show consistent neural responses to verbal instructions (51).”
• Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients (2012, positive): “For this reason, electrophysiological (Kotchoubey et al., 2005; Fellinger et al., 2011) and neuroimaging protocols (Owen et al., 2006; Monti et al., 2010a) have been developed to probe for signs of aware- ness even in patients who are completely unable to move.”
• Signature of consciousness in the dynamics of resting-state brain activity (2015, background): “Although a small proportion of VS patients show a high degree of residual cognitive activity (14, 15), this is unlikely to be the case during general anesthesia, suggesting that complex functional connectivity patterns can also arise purely as the result of a semirandom circulation of spontaneous ne”
• From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness (2011, background): “The neurological community at present has no diagnostic category for patients showing only signs of consciousness or communication on paraclinical fMRI or evoked potential studies such as the ones discussed above [19, 59].”
• Decoding subject-driven cognitive states with whole-brain connectivity patterns. (2012, methodology): “The 12 subjects from the validation cohort completed these tasks plus an additional task, in which they were asked to imagine walking through all the rooms of their house or apartment (Owen et al. 2006).”
• A Brain–Computer Interface Controlled Auditory Event‐Related Potential (P300) Spelling System for Locked‐In Patients (2009, methodology): “Step 4: volitional tasks that require the subject to actively imagine one of two actions according to two corresponding auditory stimuli, 16 , 41 or to focus attention on a specific target in a paradigm designed to elicit ERP (as described in this study and Refs.”
• Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome (2010, background): “Finally, since the term VS was coined in 1972, an increasing number of functional neuroimaging and event related potential (ERP) studies have shown that physicians should be very careful about making strong claims about patients' awareness [25-31].”