Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.

By R. Bradley, Elisabeth B. Binder, M. Epstein, Yilang Tang, H. Nair, Wei Liu, Charles F. Gillespie, Tiina Berg, Mark Evces, D. Newport and 6 more. Archives of General Psychiatry, 2008

651 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Clinical Psychology

View Paper: https://www.semanticscholar.org/paper/15547b4b1505ebeb3e8c77414f89ff814a15e091

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Citations in the corpus

Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “There is also growing evidence that such variation explains variability in how early stress affects mental health (Belsky & Pluess, 2009; Binder et al., 2008; R. G. Bradley et al., 2008; Caspi et al., 2002; Gillespie, Phifer, Bradley, & Ressler, 2009).”
Early Life Programming and Neurodevelopmental Disorders (2010, background): “Genetic polymorphisms of the CRF receptor 1 and of FK506 binding protein 5, a gene that codes a glucocorticoid receptor (GR) co-chaperone protein, have recently been implicated in the child abuse-associated increase in vulnerability to major depression and posttraumatic stress disorder, respectively”
Neurobiological and psychiatric consequences of child abuse and neglect. (2010, background): “…role for CRH systems in mediating the depressogenic effects of child abuse and neglect are observations that polymorphisms of the CRH-R1 are major determinants as to whether early-life trauma is associated with depression, an effect as large as the SERT polymorphism (Bradley et al., 2008).”
Emotional Dysregulation and Negative Affect Mediate the Relationship Between Maternal History of Child Maltreatment and Maternal Child Abuse Potential (2014, methodology): “2006; Lanius, Vermetten, and Pain 2010; Mullen, Martin, Anderson, Romans, and Herbison 1996; Silverman, Reinherz, and Giaconia 1996), and adults with histories of childhoodmaltreatment are particularly vulnerable to the development of stress-related psychopathology in adulthood (Binder et al. 2008; ”
Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect. (2016, background): “This is an extraordinarily complex area with a substantial number of studies that have documented both increased and decreased HPA axis activity as a consequence of child abuse and neglect.”
Intergenerational Trauma: Convergence of Multiple Processes among First Nations peoples in Canada (2009, positive): “Interestingly, it was shown that a genetic polymorphism (a gene mutation) will not necessarily result in expression of pathology, but may be evident provided that the individual had encountered a sufficiently severe stressful experience (Bradley et al., 2008; Caspi et al., 2003; Kaufman et al., 2004”
Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. (2012, positive): “This finding has been replicated in two additional cohorts (Bradley et al., 2008; Polanczyk et al., 2009) with different ethnicities.”
The Role of Early Life Stress as a Predictor for Alcohol and Drug Dependence (2010, background): “…published showing interactive effects between stress genes and childhood maltreatment on depression, PTSD, and suicidal behavior (for example: Binder et al. 2008, 2010; Bradley et al. 2008; Caspi et al. 2010 (review); Heim et al. 2009; Ressler et al. 2010; Roy et al. 2010; Polanczyk et al. 2009).”
Understanding resilience (2013, background): “One study identified, in two independent populations, significant gene × environment interactions with several individual SNPs of the CRHR1 gene that influenced the risk of developing adult depressive symptoms in individuals with a history of child abuse (Bradley et al., 2008).”