The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental…

By Michael Maes, B. Leonard, A. Myint, M. Kubera, R. Verkerk. Progress in Neuro-psychopharmacology and Biological Psychiatry, 2011

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Inflammation and clinical response to treatment in depression: A meta-analysis. (2015, neutral): “…response has been well documented and this system interacts bidirectionally with other systems implicated in mood disorders, including HPA-axis activity and cortisol release (Miller et al., 1999), serotonergic pathways (Maes et al., 2011), neurogenesis and neuroinflammation (Harry and Kraft, 2012).”
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, background): “…for this tryptophan depletion hypothesis of depression is provided by animal model studies, which have shown that depressive-like behaviors in rodents are mediated by an enzyme that degrades tryptophan, called indoleamine 2,3-dioxygenase (IDO; O’Connor et al., 2009; see also Maes et al., 2011).”