The hypothalamus and the control of energy homeostasis: different circuits, different purposes.

By Gareth R. Williams, C. Bing, Xue J. Cai, J. Harrold, P. King, Xiao H Liu. Physiology and Behavior, 2001

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The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. (2003, background): “The hypothalamus is also a target site for the action of hormones such as insulin and leptin, which have been largely described to be involved in the regulation of food intake and body weight (Baskin et al., 1999; Elmquist et al., 1999; Kalra et al., 1999; Proietto et al., 2000; Williams et al., 200”
Multiple neural systems controlling food intake and body weight. (2002, background): “For a thorough discussion of the rapidly accumulating literature dealing with hypothalamic peptides and the regulation of their expression, the reader is referred to several excellent recent reviews [22,38,217,267].”