Neutrophil-Derived Cytokines: Facts Beyond Expression
By C. Tecchio, A. Micheletti, M. Cassatella. Frontiers in Immunology, 2014
663 citations recorded by the source corpus.
Polymorphonuclear neutrophils, besides their involvement in primary defense against infections – mainly through phagocytosis, generation of toxic molecules, release of enzymes, and formation of extracellular traps – are also becoming increasingly important for their contribution to the fine regulation in development of inflammatory and immune responses. These latter functions of neutrophils occur, in part, via their de novo production and release of a large variety of cytokines, including chemotactic cytokines (chemokines). Accordingly, the improvement in technologies for molecular and functional cell analysis, along with concomitant advances in cell purification techniques, have allowed the identification of a continuously growing list of neutrophil-derived cytokines, as well as the characterization of their biological implications in vitro and/or in vivo. This short review summarizes crucial concepts regarding the modalities of expression, release, and regulation of neutrophil-derived cytokines. It also highlights examples illustrating the potential implications of neutrophil-derived cytokines according to recent observations made in humans and/or in experimental animal models.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/b9633d71bc20e4809080f1c41c364436e81493c0
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Citations in the corpus
- Reactive Oxygen Species and Neutrophil Function. (2016, background): “This directional movement is associated with increased phosphorylation and the accumulation of phosphatidylinositol (3,4,5) triphosphate at the leading edge (89).”
- Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “It was already mentioned that in fact neutrophils are transcriptionally active cells with the potential to change the expression of several membrane molecules, and to produce cytokines (Tecchio et al., 2014; Tecchio and Cassatella, 2016), and consequently neutrophils are capable of performing differ”
- Acute Chorioamnionitis and Funisitis: Definition, Pathologic Features, and Clinical Significance (2015, background): “OCTOBER 2015 Am peptide, and CXCL6, a granulocyte chemotactic protein).(215,216,296) Intraamniotic inflammation due to microorganisms or “danger signals” can result in the production of the following chemokines: IL-8(26,187-189,196,199,200,202,206-210), macrophage inhibitory cytokine,(297,298) MCP,(”