Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades

551 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Biomolecular computing systems: principles, progress and potential (2012, methodology): “From initial experimental computations with a four-gate circuit integrating six microRNA-like inputs 63 in the test tube, these circuits have grown to include up to twelve gates, eight inputs and more than 100 building blocks 64 .”
Toehold Switches: De-Novo-Designed Regulators of Gene Expression (2014, unknown): “, 2010) and for complex in vitro information processing systems (Qian and Winfree, 2011; Qian et al., 2011; Yin et al., 2008).”
Programmable chemical controllers made from DNA (2013, methodology): “The DNA-only construction of digital logic circuits and Boolean neural networks with over a hundred rationally designed parts forms possibly the most dramatic demonstration of a systematic engineering approach to building molecular circuits 16,17 .”
Large-scale de novo DNA synthesis: technologies and applications (2014, background): “Base-pairing and strand-invasion properties of DNA have also allowed researchers to explore interesting information processing and computational capabilities using small libraries of oligos [129] [130] [131] [132] .”