The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

By Dennis A. Smith, Li Di, Edward H. Kerns. Nature reviews. Drug discovery, 2010

822 citations recorded by the source corpus.

Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/147cac3c14e46448f72d8627ce25e99360885468

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In Molecular Biology

1. W. Charman
2. Colin W. Pouton
3. Christopher J. H. Porter
4. S. Charman
5. H. Williams
6. R. Shanker
7. Natalie L. Trevaskis

Citations in the corpus

• Strategies to Address Low Drug Solubility in Discovery and Development (2013, background): “For a more comprehensive review of the effect of protein binding on the pharmacological activity of drugs and the complexities of interpreting static (in vitro) versus dynamic (in vivo) situations, the reader is referred to the excellent review by Smith et al. (2010).”