High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors.

By I. Rincón, K. Williams, M. Stern, G. Freeman, A. Escalante. Arthritis & Rheumatism, 2001

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EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis (2009, background): “Moreover, the excess CV burden persists after adjustment for traditional CV risk factors.”
Cardiovascular death in rheumatoid arthritis: a population-based study. (2005, background): “Fourth, systemic inflammation in RA may act independently of traditional risk factors to increase the risk through biologic mechanisms (21,51,52).”
National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2. (2015, background): “These data suggest that in an individual RA patient, LDL-C levels may increase when RA disease activity is controlled.(728,729) Although the overall reduction in inflammation is likely associated with reduced cardiovascular risk, the clinical significance of these lipid elevations with regards to ca”