Beyond neurons: evidence that immune and glial cells contribute to pathological pain states.
By Linda R. Watkins, S. Maier. Physiological Reviews, 2002
740 citations recorded by the source corpus.
Subfields: Neurology, Physiology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/145f6ca4e0b664a9331a79466d3ca6068c281073
How researchers see this paper
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In Neurology
- Linda R. Watkins
- M. Hanani
- Kevin J. Tracey
- S. Maier
- E. Milligan
- Clifford J. Woolf
- R. Ji
- Bruce S. McEwen
In Physiology
- Linda R. Watkins
- S. Maier
- E. Milligan
- M. Hanani
- Kevin J. Tracey
- Clifford J. Woolf
- R. Ji
- G. Moalem-Taylor
In Psychiatry and Mental health
Citations in the corpus
- Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity (2009, neutral): “by microglial cells themselves or by astrocytes and T-cells.(1,3,66,76,204,348,361,362) Release of cytokines by microglia increases neuronal excitability through activation of ERK and CREB.”
- GLIA: A novel drug discovery target for clinical pain (2003, background): “For example, injured peripheral nerves can exhibit a number of changes: spontaneous activity can occur that signals the presence of noxious stimuli despite the fact that no such stimulus is present; novel receptors for stress hormones can be expressed, such that sympathetic activation subsequently e”
- Spinal Glia and Proinflammatory Cytokines Mediate Mirror-Image Neuropathic Pain in Rats (2003, background): “Although neuropathic pain is perceived to arise from the skin innervated by the damaged/inflamed nerve, pathological pain can also arise from sites contralateral to (the mirror image of) the site of pathology (Watkins and Maier, 2002).”
- Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain (2013, background): “Importantly, Schwann cells rapidly release the chemo-attractant CCL2 upon nerve damage that in turn recruits monocytes and T cells to the site of the nerve degeneration [10].”
- Satellite glial cells in sensory ganglia: from form to function. (2005, background): “It was suggested that SGCs release cytokines [181], and thus can influence DRG neurons, which possess IL-1 receptors [30].”