Mapping of genetic and epigenetic regulatory networks using microarrays

By B. van Steensel. Nature Genetics, 2005

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Genome-wide analysis of estrogen receptor binding sites (2006, unknown): “It is of interest to note that there are many more estrogen receptor binding sites in the genome than differentially regulated genes, as has been previously suggeste”
Evolutionary genetics of genome merger and doubling in plants. (2008, methodology): “Because of this linkage, a potentially valuable approach would be to examine histone and chromatin states in various polyploid/diploid systems using methods such as chromosomal immunoprecipitation on microarray chips (ChIP-on-Chip) (58, 89, 95, 110, 118).”
A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. (2007, background): “While it is likely that many of these sites act as transcriptional enhancers of neighboring genes, other functions may also exist.Inaddition, itislikelythatonlyasubsetofthebinding sites are functional in LNCaP under the specific experimentalconditionstestedandmaybefunctionalindifferent cell types an”
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. (2006, background): “Their large size would ensure that each daughter chromosome would likely inherit a substantial proportion of the modified histones, which could then promote similar modification of new histones in the immediate vicinity (Henikoff et al., 2004; van Steensel, 2005).”