Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

By K. Falkenberg, Ricky W. Johnstone. Nature reviews. Drug discovery, 2014

1,453 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/143a01a9ececba562cb400b7ed92f24bf7c889e0

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Citations in the corpus

Systematic mapping of functional enhancer-promoter connections with CRISPR interference (2016, background): “Interestingly, histone deacetylases are required for erythropoiesis (18) and HDAC6 has been implicated in cellular proliferation in multiple cancers (19).”
Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice (2015, background): “HDAC6 in particular appears to be involved in mood control, in tau-driven neurological disorders, in the progression of Alzheimer’s and Huntington’s diseases, in immune synapse formation, and in regulatory T-cell homeostasis (16).”
Astrocyte crosstalk in CNS inflammation (2020, background): “HDACs have long been targeted in neurological disorders (Falkenberg and Johnstone, 2014) and multiple reports support a role of HDACs in astrocyte activation and neuroimmune crosstalk (Beurel, 2011; Correa et al.”
Acetyl coenzyme A: a central metabolite and second messenger. (2015, background): “Some HDAC inhibitors including suberanilohydroxamic acid (SAHA, best known as vorinostat) and romidepsin are approved by international regulatory agencies for use in cancer patients (Falkenberg and Johnstone, 2014).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “For more information about the usage of HDAC inhibitors, IDH1/2 inhibitors, SAM cycle inhibitors and other inhibitors or activators of epigenetic modulation in cancer, please see the excellent reviews by Falkenberg et al., Eckschlager et al., Wong et al. and Cheng et al. (Falkenberg and Johnstone, 2”
Post-translational modifications in proteins: resources, tools and prediction methods (2021, background): “According to the available evidence, acetylated lysine is vital for cell development, and its dysregulation would lead to serious diseases such as cancer, aging, immune disorders, neurological diseases (Huntington’s disease and Parkinson’s disease) and cardiovascular diseases (56, 59, 60, 61).”