Geometrically mediated breakup of drops in microfluidic devices.
By D. Link, S. Anna, David A. Weitz, Howard A. Stone. Physical Review Letters, 2003
1,096 citations recorded by the source corpus.
Microfluidic technology offers capabilities for the precise handling of small fluid volumes dispersed as droplets. To fully exploit this potential requires simultaneous generation of multiple size droplets. We demonstrate two methods for passively breaking larger drops into precisely controlled daughter drops using pressure-driven flow in simple microfluidic configurations: (i) a T junction and (ii) flow past isolated obstacles. We quantify conditions for breakup at a T junction and illustrate sequential breakup at T junctions for making small drops at high dispersed phase volume fractions.
Subfields: Biomedical Engineering, Electrical and Electronic Engineering
View Paper: https://www.semanticscholar.org/paper/13e656f1539d3ecbd03043922ea808634006a288
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
- T. Squires
- Stephen R. Quake
- G. Vladisavljević
- A. Ajdari
- George M. Whitesides
- I. Kobayashi
- Roland Zengerle
- S. Haeberle
In Electrical and Electronic Engineering
- T. Squires
- G. Vladisavljević
- Roland Zengerle
- S. Haeberle
- A. Ajdari
- David A. Weitz
- David J. Beebe
- Stephen R. Quake
Citations in the corpus
- Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. (2010, methodology): “Using a similar method, the formation of droplet emulsions with controlled volume fractions and drop sizes has been realized [156].”
- Hydrodynamics of a droplet passing through a microfluidic T-junction (2017, background): “Since Link et al. (2004) pioneered the introduction of T-junctions to passively split droplets into miniature sizes, considerable effort has been devoted to elucidating the mechanism of droplet breakup in a microfluidic T-junction.”
- Lab-on-a-chip: microfluidics in drug discovery (2006, methodology): “Having generated the droplets, different methods of droplet handling and manipulation such as fission, fusion and sortin”
- A brief review of the phase-field-based lattice Boltzmann method for multiphase flows (2019, methodology): “In the past decades, the experimental method has been widely used to study the multiphase flow problems, and can also capture the macroscopic dynamic behavior of interface (Link et al., 2004; Jullien et al., 2009; Kintses et al., 2010), while it is difficult to accurately describe the details of the”