Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus

By T. Tumpey, C. Basler, P. Aguilar, H. Zeng, A. Solórzano, D. Swayne, N. Cox, J. Katz, J. Taubenberger, P. Palese and 1 more. Science, 2005

1,271 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/13d1d98752d97e568582a74dd10caa4608fe0a57

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. J. Taubenberger
2. A. García‐Sastre
3. D. Morens
4. P. Palese
5. A. Fauci
6. Jonathan A. McCullers
7. J. Kash
8. J. Peiris

In Immunology

1. A. García‐Sastre
2. P. Palese
3. G. van Loo
4. Edward M. Marcotte
5. Jonathan A. McCullers
6. Shizuo Akira
7. R. Medzhitov
8. Taro Kawai

Citations in the corpus

• A Synthetic Genetic Edge Detection Program (2009, background): “Other functional DNA elements used in the construction of the edge detector are the weak ribosome binding site RBS3(Weiss, 2001) and the ORF of the lacZ gene.”
• Synthetic Biology: Social and Ethical Challenges (2008, background): “Three years later another team of scientists published a paper in Science announcing they had sequenced and built the pandemic Spanish Flu virus of 1918 [Tumpey et al. 2005], which killed an estimated 20-50 million people worldwide.”
• THE BIOLOGY OF INFLUENZA VIRUSES (2008, background): “Characterization of the reconstructed 1918 influenza virus indicated that its unique constellation of genes was responsible for its extreme virulence, with the HA, NA, and PB1 genes all contributing to its high pathogenicity [16, 17 ].”
• H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice (2008, methodology): “As shown in Figure 1, the 1918 (H1N1) and A/Thailand/16/2004 (Thai/16, H5N1) viruses replicated to high titers that were at least 5-fold higher than the respective LP viruses, A/Texas/36/91 (TX/91, H1N1) and A/Thailand/SP/83/2004 (SP/83, H5N1) as early as 1 day post-infection (p.i.) and sustained hi”
• Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “Interestingly, the virulence of the reconstructed 1918 Spanish flu was also dependent on the whole polymerase gene complex rather than on individual mutations (235) and was attributed to enhanced virus replication competence.”
• Influenza Virus Evolution, Host Adaptation and Pandemic Formation (2010, background): “, 2001); yet the 1918 virus is extremely virulent in mice (Tumpey et al., 2005).”
• Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury (2008, background): “ARDS was also the cause of death in millions of people during the Spanish Influenza pandemic (Tumpey et al., 2005).”
• Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness (2008, background): “With the recent reconstruction of the 1918 pandemic influenza virus, investigators have begun to examine why it was so highly fatal [6, 7].”