Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

By R. Russell, Nelson B. Watts, F. Ebetino, M. Rogers. Osteoporosis International, 2008

1,406 citations recorded by the source corpus.

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Denosumab and bisphosphonates: different mechanisms of action and effects. (2011, methodology): “Different bisphosphonates contain different R1 and R2 groups and, as a consequence, vary in their binding affinity and biochemical potency [39,44,49,53].”
Impact of Dental Implant Surface Modifications on Osseointegration (2016, background): “Bisphosphonates are antiresorptive drugs that influence bone metabolism mainly by inhibition of osteoclasts [115].”
Bisphosphonates: the first 40 years. (2011, background): “A recent search in PubMed under the term ‘bisphosphonates’ revealed over 19,000 publications, and even this large list this does not cite abstracts, nor all publications and the many books and review articles available that describe the chemistry, pharmacology, and clinical applications of bisphosph”