3D Bioprinting of Vascularized, Heterogeneous Cell‐Laden Tissue Constructs

By David Kolesky, Ryan L. Truby, A. Gladman, Travis A. Busbee, K. Homan, J. Lewis. Advances in Materials, 2014

1,877 citations recorded by the source corpus.

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/13a1f455125ab104a7a9cca846a09931da2e80c2

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Citations in the corpus

The Emerging Frontiers and Applications of High-Resolution 3D Printing (2017, methodology): “Organs-on-chips are microfluidic devices for culturing microengineered tissues within continuously-perfused microbioreactor to mimic physiological functions of tissues and facilitate screening of new therapeutics such as liver, heart, and skin [35,36].”
A review of 3D-printed sensors (2017, background): “Meanwhile, some thermoresponsive and biocompatible materials, which are suitable for using in biology, have also been applied in the 3D printing technology, such as Poloxamer 407 (144), Aqueous Pluronic F127 (145), gelatin methacrylate (GelMA) (146), and a visible light-based material that can get r”
A Review of Three-Dimensional Printing in Tissue Engineering (2016, positive): “The Lewis group from the Wyss Institute have expanded upon these techniques to create scaffolds using sacrificial inks to create vasculatures on the order of hundreds of microns in size with the potential to create scaffolds with many materials and cell types.(43,44) Extrusion-based printers typical”
3D Bioprinting for Engineering Complex Tissues (2015, methodology): “Thelatestver-sions of extrusion printers include tissue – vessel parallel printing (Ozbolat et al., 2014) and parallel multi-bioink printing (Kolesky et al., 2014).”