The Ctenophore Genome and the Evolutionary Origins of Neural Systems
By L. Moroz, K. Kocot, M. Citarella, Sohn Dosung, T. Norekian, I. Povolotskaya, A. Grigorenko, Christopher Dailey, E. Berezikov, Katherine M. Buckley and 26 more. Nature, 2014
660 citations recorded by the source corpus.
The origins of neural systems remain unresolved. In contrast to other basal metazoans, ctenophores (comb jellies) have both complex nervous and mesoderm-derived muscular systems. These holoplanktonic predators also have sophisticated ciliated locomotion, behaviour and distinct development. Here we present the draft genome of Pleurobrachia bachei, Pacific sea gooseberry, together with ten other ctenophore transcriptomes, and show that they are remarkably distinct from other animal genomes in their content of neurogenic, immune and developmental genes. Our integrative analyses place Ctenophora as the earliest lineage within Metazoa. This hypothesis is supported by comparative analysis of multiple gene families, including the apparent absence of HOX genes, canonical microRNA machinery, and reduced immune complement in ctenophores. Although two distinct nervous systems are well recognized in ctenophores, many bilaterian neuron-specific genes and genes of ‘classical’ neurotransmitter pathways either are absent or, if present, are not expressed in neurons. Our metabolomic and physiological data are consistent with the hypothesis that ctenophore neural systems, and possibly muscle specification, evolved independently from those in other animals.
Subfields: Cellular and Molecular Neuroscience, Paleontology, Plant Science
View Paper: https://www.semanticscholar.org/paper/137f0975e8e4703006b29b61633b8cf3a650088f
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In Cellular and Molecular Neuroscience
In Paleontology
- Gonzalo Giribet
- G. Edgecombe
- Casey W. Dunn
- A. Hejnol
- Sarah L. Boyer
- Zhi-qiang Zhang
- Prashant P. Sharma
- A. Kury
In Plant Science
- David P. Bartel
- Olivier Voinnet
- H. Vaucheret
- Jian‐Kang Zhu
- A. Turner
- B. Bartel
- A. Mallory
- Ramanjulu Sunkar
Citations in the corpus
- Animal Phylogeny and Its Evolutionary Implications (2014, background): “The recently sequenced genomes of two ctenophores (Ryan et al. 2013, Moroz et al. 2014) now makes this possible, and analyses of gene gain and loss support the placement of ctenophores, rather than sponges, as the sister group to all other animals.”
- Metazoan MicroRNAs (2018, background): “, 2017), miRNAs were lost in both the placozoan and ctenophore lineages (Grimson et al., 2008; Moroz et al., 2014).”
- Morphology should not be forgotten in the era of genomics—a phylogenetic perspective (2015, neutral): “ Many other analyses followed, especially re-‐evaluating the 94 base of the animal tree (e.g., Lartillot and Philippe, 2008; Moroz et al., 2014; Philippe et al., 95 2009; Pick et al., 2010; Ryan et al., 2013), or some of its largest clades (e.g., Andrade…”
- Third generation sequencing: technology and its potential impact on evolutionary biodiversity research (2016, neutral): “All Rights Reserved. http://dx.doi.org/10.1080/14772000.2015.1099575 Bleidorn, 2014; Johnson, Walden, & Robertson, 2013; Lemmon, Emme, & Lemmon, 2012; Misof et al., 2014; Moroz et al., 2014; Weitemier et al., 2014).”