Ubiquitin ligases: cell-cycle control and cancer

By K. Nakayama, Keiko Nakayama. Nature Reviews. Cancer, 2006

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HECT and RING finger families of E3 ubiquitin ligases at a glance (2012, background): “One of two co-activators, cell division cycle homologue 20 (CDC20) and CDH1 (officially known as FZR1) confers substrate specificity by associating with the APC/C at specific stages of the cell cycle (Nakayama and Nakayama, 2006; Peters, 2006).”
The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “As mentioned before, SCF E3 ligases are also a well-known family of E3 ligases and includes FBXW7, SKP2 and β-TrCP1.(396) Since FBPs are responsible for the specificity of SCFs, many small molecules have been designed to target them and may provide attractive therapeutic agents.”
Cdks, cyclins and CKIs: roles beyond cell cycle regulation (2013, background): “The periodic expression of cyclins is achieved by the cell cycle-dependent activation of the transcription factors E2F and FoxM1, whereas the oscillating proteolysis of cyclins is mediated through the concerted actions of two E3 ubiquitin ligase families: the Skp1-Cul1-F-box protein (SCF) complex, w”
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. (2008, background): “In addition to being regulated at the transcriptional and posttranslational levels, the cell cycle is controlled by ubiquitin (Ub)-mediated proteolysis (Figure 1A) (Ang and Harper, 2004; Nakayama and Nakayama, 2006).”