Inositol trisphosphate and calcium signalling mechanisms.
By M. Berridge. Biochimica et Biophysica Acta, 2009
806 citations recorded by the source corpus.
Studies on control of fluid secretion by an insect salivary gland led to the discovery of inositol trisphosphate (IP3) and its role in calcium signalling. Many cell stimuli act on receptors that are coupled to phospholipase C that hydrolyses phosphatidylinosol 4,5-bisphosphate (PIP2) to release IP3 to the cytosol. IP3 receptors located on the endoplasmic reticulum respond to this elevation of IP3 by releasing Ca2+, which is often organized into characteristic spatial (elementary events and waves) and temporal (Ca2+ oscillations) patterns. This IP3/Ca2+ pathway is a remarkably versatile signalling system that has been adapted to control processes as diverse as fertilization, proliferation, contraction, cell metabolism, vesicle and fluid secretion and information processing in neuronal cells.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/5d1490fca4cdbe9d4808b73216229ca83f2fbee8
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Citations in the corpus
- Calcium Signals: The Lead Currency of Plant Information Processing (2010, background): “…while higher plants lack classical endoplasmic reticulum (ER)-localized IP3 receptors, which are well known and characterized in animals (Berridge, 2009), several algae species, such as Volvox and Chlamydomonas, appear to harbor these receptor channels, suggesting that this channel type…”
- Is My Network Module Preserved and Reproducible? (2011, background): “All of these pathways have been shown to play critical roles in normal brain development and function [37–41].”