A PUF family portrait: 3'UTR regulation as a way of life.

By M. Wickens, D. Bernstein, J. Kimble, R. Parker. Trends in Genetics, 2002

650 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/12451c2681a892313b62e3a9622c95a59ee96551

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In Molecular Biology

Citations in the corpus

Extensive Association of Functionally and Cytotopically Related mRNAs with Puf Family RNA-Binding Proteins in Yeast (2004, background): “The conserved motifs we identified in the Puf3p, Puf4p, and Puf5p targets each include a UGUR tetranucleotide sequence, which is a feature of all previously reported RNA targets of Puf family proteins (Wickens et al. 2002).”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “Finally, many mRNA specific regulatory factors, (e.g., miRNAs or PUF proteins), both repress translation and accelerate deadenylation and decapping (reviewed in Wickens et al. 2002; BehmAnsmant et al. 2006; Franks and Lykke-Anderson 2008; Shyu et al. 2008).”
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP (2010, result): “We obtained 7523 clusters originating from about 3000 unique transcripts, 93% of which were found within the 30 untranslated region (UTR) (Figure S1) in agreement with previous studies (Wickens et al., 2002).”
Nuclear DNA analyses in genetic studies of populations: practice, problems and prospects (2003, background): “Promoters and other regulatory elements are present at the 5′ flanking region of a gene, and sequences at the 3′ noncoding region are necessary for post-transcriptional processing, transcription and translation regulation, and/or stability of mRNA (Ross 1996; Wickens et al. 2002).”
PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data (2011, background): “While QKI is a well-studied splicing factor in the nucleus [10], Pumilio RBPs are involved in mRNA stability and translation in the cytoplasm [11].”
A universal framework for regulatory element discovery across all genomes and data types. (2007, background): “, 2004) and thus might be bound by one (or several) of the PUF proteins in worm (Wickens et al., 2002).”
High-dimensional switches and the modeling of cellular differentiation (2004, background): “• The PUF family of proteins represses the expression of many genes by regulating their mRNA stability (Wickens et al., 2002), and has been proposed to have the ancestral function of maintaining proliferation of stem cells; in C.”