Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

By M. Kreek, D. Nielsen, E. Butelman, Steven K. LaForge, K Steven Laforge. Nature Neuroscience, 2005

1,031 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Experimental and Cognitive Psychology, Genetics

View Paper: https://www.semanticscholar.org/paper/11d5f125dd2acccd9a5091f5e30abe80a3104c1d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Spanagel
2. C. Sanchis‐Segura
3. Marilyn Carroll
4. A. Lawrence
5. Fulton Crews
6. Luke Clark
7. Charlotte A. Boettiger
8. J. Perry

In Experimental and Cognitive Psychology

1. C. Sanchis‐Segura
2. A. Lawrence
3. Fulton Crews
4. Luke Clark
5. Charlotte A. Boettiger
6. R. Spanagel
7. Antonio Verdejo-García

In Genetics

1. R. Spanagel

Citations in the corpus

• The role of impulsive behavior in drug abuse (2008, background): “For example, variants of the dopamine transporter, the dopamine D4 receptor, and the serotonin transporter have been linked to both impulsivity and alcoholism (Kreek et al. 2005), and understanding how each of these impacts impulsivity and alcoholism may yield new pharmacotherapies that decrease bot”
• Impulsivity, Frontal Lobes and Risk for Addiction (2009, background): “Polymorphisms in several genes in the dopaminergic system, which targets the frontal and limbic brain structures that regulate impulsive behavior, have been identified as likely contributors to impulsivity (Kreek et al., 2005).”
• Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “It is important to note that the impact of personality and/or neurocognitive variables may differ across various stages of addiction, from initiation, to regular use, to dependence and later on at relapse (Kreek et al., 2005).”
• REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview (2006, background): “Such a behavioural pattern presents clear similarities with the notion of impulsivity, which is considered an important temperamental [7] factor in the vulnerability towards drug addiction (Kelley, Schochet & Landry 2004; Kreek et al. 2005) and that underlies to several criteria of the DSM-IV diagno”
• Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “There is considerable evidence for heritability in drug addiction (Kreek et al., 2005; Uhl, 2006), but a large number of genes have been implicated for many different pharmacological classes of drugsofabusethattranscendthemoleculardifferencesinmodes of action that characterize these drugs.”