Impulsivity, Frontal Lobes and Risk for Addiction
By Fulton Crews, Charlotte A. Boettiger. Pharmacology, Biochemistry and Behavior, 2009
697 citations recorded by the source corpus.
Alcohol and substance abuse disorders involve continued use of substances despite negative consequences, i.e. loss of behavioral control of drug use. The frontal cortical areas of brain oversee behavioral control through executive functions. Executive functions include abstract thinking, motivation, planning, attention to tasks and inhibition of impulsive responses. Impulsiveness generally refers to premature, unduly risky, poorly conceived actions. Dysfunctional impulsivity includes deficits in attention, lack of reflection and/or insensitivity to consequences, all of which occur in addiction (Evenden, 1999; (de Wit, 2009). Binge drinking models indicate chronic alcohol damages corticolimbic brain regions (Crews et al., 2000) causing reversal learning deficits indicative of loss of executive function (Obernier et al., 2002b). Genetics and adolescent age are risk factors for alcoholism that coincide with sensitivity to alcohol induced neurotoxicity. Cortical degeneration from alcohol abuse may increase impulsivity contributing to the development, persistence and severity of alcohol use disorders. Interestingly, abstinence results in bursts of neurogenesis and brain regrowth (Crews and Nixon, 2009). Treatments for alcoholism, including naltrexone pharmacotherapy and psychotherapy may work through improving executive functions. This review will examine the relationships between impulsivity and executive function behaviors to changes in cortical structure during alcohol dependence and recovery.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/c9aaaf829fda56cdcc405d371db5ced3d659b019
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- Cognitive Bias Modification and Cognitive Control Training in Addiction and Related Psychopathology (2013, background): “…strong experimental evidence from animal research that excessive use of alcohol and drugs (especially during adolescence) has strong effects on subsequent brain development involving cognitive and emotional regulatory processes (Crews & Boettiger, 2009; Nasrallah, Yang, & Bernstein, 2009).”