Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

By C. Auffray, D. Fogg, M. Garfa, Gaelle Elain, O. Join-Lambert, S. Kayal, S. Sarnacki, A. Cumano, G. Lauvau, F. Geissmann. Science, 2007

2,027 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Repertoire of microglial and macrophage responses after spinal cord injury (2011, neutral): “Intravital microscopy in mice with CX3CR1 GFP -labelled GR1 − resident monocytes showed that in the skin and mesenteric vessels, these monocytes exhibit patrolling behaviour”
Two physically, functionally, and developmentally distinct peritoneal macrophage subsets (2010, background): “1; Alexa700labeled anti-IgD (11-26); APCCy7-labeled anti-CD11b (M1/70); Pacific Blue– labeled anti-F4/80 (BM8) or Gr-1 (RB6-8C5) and biotin-labeled anti-CD11c (HL3).”
Monocytes in atherosclerosis: subsets and functions (2010, background): “A series of in vivo experiments in mice have pushed forward the concept that, in addition to plasticity, the heterogeneity of blood monocytes is a major determinant of their effector functions”
Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, methodology): “Intravital microscopy observation, using Cx3cr1gfp/+ mice as reporters, revealed that Ly6C− (Gr1−) monocytes exhibited a constitutive long-range crawling on the luminal side of the endothelium, in steady-state condition, within most blood vessels in the dermis and within branches of the mesenteric v”
The chemokine system in innate immunity. (2015, background): “CX3CR1 has been shown to play an essential role in promoting integrin-mediated adhesion within the vessel, which allows for the patrolling phenotype of CX3CR1þmonocytes (Auffray et al. 2007).”