The IL-1 family and inflammatory diseases.

By C. A. Dinarello. Clinical and Experimental Rheumatology, 2002

665 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/11b7e1f3a3306b1c8f9d0f65b744c73a82a5247a

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Citations in the corpus

• Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade (2005, background): “The IL-1 family includes nine members (26), eight of which were not upregulated using real-time PCR in patients’ PBMCs (unpublished data).”
• The role of cytokines in cartilage matrix degeneration in osteoarthritis. (2004, background): “kines and revealed the unexpected diversity and pleiotropy of their biologic activities.(7,31,35) With respect to regulation of chondrocyte function, it is possible to classify the cy-”
• NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 (2009, unknown): “…Mediate Neutrophil, Monocyte, and DC Recruitment The proinflammatory cytokine IL-1b is known to be a potent pyrogen that increases the expression of adhesion factors on endothelial cells to facilitate the transmigration of leukocytes (Dinarello, 2002, 2005, 2006; Wewers, 2004; Wewers et al., 1997).”
• Dengue and severe dengue (2025, unknown): “Interleukin-1 (IL-1) has been implicated in dengue pathogenesis (298–300).”
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release1 (2006, background): “In contrast to IL1 , IL-18 is not an endogenous pyrogen (2).”
• BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. (2018, background): “In addition, IL-1b is well known to exert strong effects on myelopoiesis (Dinarello, 2002), and one may hypothesize that IL-1b represents the endogenous mediator between the peripheral stimulation of monocytes and macrophages by BCG and long-term functional reprogramming at the level of bone marrow ”
• The P2X7 Receptor in Infection and Inflammation (2017, unknown): “Interleukin-1b is an atypical cytokine that lacks a secretory piece, thus it does not follow the canonical endoplasmic reticulum route for release into the extracellular environment (Dinarello, 2002).”