The metabolism of cancer cells during metastasis

By G. Bergers, S. Fendt. Nature Reviews. Cancer, 2021

759 citations recorded by the source corpus.

Metastasis formation is the major cause of death in most patients with cancer. Despite extensive research, targeting metastatic seeding and colonization is still an unresolved challenge. Only recently, attention has been drawn to the fact that metastasizing cancer cells selectively and dynamically adapt their metabolism at every step during the metastatic cascade. Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment. Consequently, the stage-dependent metabolic traits may provide therapeutic windows for preventing or reducing metastasis, and targeting the new metabolic traits arising in established metastases may allow their eradication. This Review describes the metabolic rewiring that occurs in cancer cells transitioning through the metastatic cascade and discusses the evidence for metabolically distinct features of primary tumours and metastases.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/119b5ca90eba104c3ac2caf78aa9f7ceb8dedd1d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

  1. Thomas Brabletz
  2. Harald Schuhwerk
  3. Simone Brabletz
  4. Marc P. Stemmler
  5. M. Nieto

In Molecular Biology

  1. Simone Brabletz
  2. Thomas Brabletz
  3. Marc P. Stemmler
  4. Harald Schuhwerk
  5. R. Weinberg
  6. M. Nieto
  7. D. Hanahan

Citations in the corpus