Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.

By M. Thompson, C. Fuller, T. Hogg, J. Dalton, D. Finkelstein, C. Lau, M. Chintagumpala, A. Adesina, D. Ashley, S. Kellie and 4 more. Journal of Clinical Oncology, 2006

669 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1148822e013f130020eba484177582608a8fecf5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Richard J. Gilbertson
2. Eric C. Holland

In Molecular Biology

1. Bauke Ylstra
2. Richard J. Gilbertson
3. Eric C. Holland
4. Jason T. Huse

Citations in the corpus

• Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features (2008, methodology): “[30] using the 1500 most differentially expressed Medulloblastoma Subtypes”
• Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma (2010, background): “More recently, two integrated genomic investigations have revealed distinct transcriptional subclasses of medulloblastoma that also harbour genomic alterations in oncogenic signalling pathway”
• A perivascular niche for brain tumor stem cells. (2007, methodology): “First, we performed consecutive coimmunofluorescence (Nestin and CD34) and fluorescence in situ hybridization (FISH) analysis of sections of medulloblastomas that we had shown previously to contain an isochromosome of 17q (Thompson et al., 2006).”
• Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas (2012, methodology): “Several of the earlier profiling studies showed that there might even be five or six subgroups of medulloblastoma [1, 9, 25], with further subdivisions of Group 3 and Group 4.”
• Medulloblastoma comprises four distinct molecular variants. (2011, background): “Both studies clearly show the WNT group of tumors clustering alone, whereas SHH-driven tumors did not always segregate as a single subgroup.(26) Both the current data set and the data set from Kool et al(16) show that although WNT tumors are classic medulloblastomas and most desmoplastic medulloblas”
• Molecular subgroups of medulloblastoma: the current consensus (2011, methodology): “Others approaches to identify Shh medulloblastomas have included immunohistochemical staining for SFRP1 [2, 28, 48], or GAB1 [11].”