Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

By Cécile Guichard, G. Amaddeo, S. Imbeaud, Y. Ladeiro, L. Pelletier, I. B. Maad, J. Calderaro, P. Bioulac-Sage, M. Letexier, F. Degos and 8 more. Nature Genetics, 2012

1,390 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/112e068494415a4636e00b2232251e7a5244cdca

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In Cancer Research

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In Molecular Biology

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In Pathology and Forensic Medicine

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Citations in the corpus

• Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma (2017, positive): “Overall patterns of broad and focal alterations across the entire cohort were similar to earlier reports (Guichard et al., 2012; Totoki et al., 2014) (Figure S2A).”
• Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification (2020, background): “This mutation was present with CTNNB1 mutations, potentiating alterations of the oxidative stress pathway in WNT/βcatenin signaling (Guichard et al., 2012).”
• Human Primary Liver Cancer -derived Organoid Cultures for disease modelling and drug screening (2017, positive): “Dataset 4) in agreement with the differential mutational pattern of these 2 360 components of the Wnt pathway in these 2 subtypes of liver tumours [52, 53, 54].”
• Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. (2017, methodology): “For additional cases, genomic DNA was extracted using a Promega Maxwell Instrument and samples were further sequenced for TERT promoter, CTNNB1, TP53, AXIN1, ALB, APOB, ARID1A, ARID2, NFE2L2, ATM, TSC1/TSC2 and RPS6KA3, using a MiSeq instrument (Illumina, San Diego, CA, USA) (Supplementary material ”