Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

By Zhuohua Zhang, P. Nadeau, Weihong Song, D. Donoviel, M. Yuan, A. Bernstein, B. Yankner. Nature Cell Biology, 2000

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aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation (2002, background): “…and -secretase inhibitors and are abolished in PS-deficient Notch substrates and reduces the levels of processed mouse cells (Herreman et al., 2000; Zhang et al., 2000) presenilin. aph-1 and pen-2, like nicastrin, are required and in presenilin (psn) mutant Drosophila embryos for the activity and…”
Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates (2003, positive): “Studies have shown decreased A production in neurons derived from PS knockout embryos (De Strooper et al., 1998; Herreman et al., 2000; Zhang et al., 2000), and it has also been demonstrated in vitro that mutation of either one of two conserved aspartate residues, one in TM6 and the other in TM7 of ”