Neurobiology of Periventricular Leukomalacia in the Premature Infant

By Joseph J. Volpe. Pediatric Research, 2001

987 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

White and gray matter development in human fetal, newborn and pediatric brains (2006, background): “It has been postulated that injuries of specific white matter tracts in cerebral palsy are due to an incomplete state of development of the vascular supply to the cerebral white matter and the maturation-dependent vulnerability of the oligodendroglia precursor cells (the timing of insults and active”
Ferroptosis: Death by Lipid Peroxidation. (2016, background): “Periventricular leukomalacia (PVL) is a form of white-matter brain injury that underlies most of the neurologic morbidity encountered by many premature infants [65].”
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia (2005, result): “These results suggest either (1) the presence of a subunit (perhaps NR3) that suppresses modulatory actions on NR2 subunits, or (2) the presence of a combination of subunits that these agents modulate in opposite directions (for example, NR1/NR2A/NR2C or NR1/NR2/NR3), or (3) a mixture of receptors w”
Tract Profiles of White Matter Properties: Automating Fiber-Tract Quantification (2012, background): “Studies of preterm infants report heterogeneous outcomes including diffuse abnormalities in the myelination process due to damage to oligodendrocyte precursor cells, focal necrotic lesions due to severe hypoxic/ischemic insult, and typical white matter development despite neonatal complications [35]”