Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.

By J. Haeggström, C. Funk. Chemical Reviews, 2011

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Immunity, atherosclerosis and cardiovascular disease (2013, background): “Another example of an interesting group of inflammatory compounds is lipid mediators, such as leukotrienes, which are present in advanced atherosclerotic plaques [79,80].”
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis (2016, background): “Fatty acid hydroperoxides are then converted to fatty acid alcohols, generating lipid-signaling molecules, such as eicosanoids (31).”
Ferroptosis: Death by Lipid Peroxidation. (2016, background): “A candidate family of enzymes with this property is the family of lipoxygenases that catalyze the dioxygenation of polyunsaturated fatty acids in lipids [86].”
Mammalian lipoxygenases and their biological relevance (2014, background): “The ALOX5 gene encodes for a 5-lipoxygenating enzyme, which plays a major role in leukotriene biosynthesis [2, 33].”