Cross-tissue organization of the fibroblast lineage

By M. Buechler, R. Pradhan, Akshay T. Krishnamurty, Christian B. Cox, Aslihan Karabacak Calviello, Amber W Wang, Y. Yang, Lucinda Tam, R. Caothien, Merone Roose-Girma and 5 more. Nature, 2021

874 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/10361e866b10225439febe059e9ece4c4c1ddc93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. P. Seale
2. Stephen R. Quake
3. Xiawei Wei

In Oncology

1. Stephen R. Quake
2. Xiawei Wei

Citations in the corpus

• Targeting TGF-β signal transduction for fibrosis and cancer therapy (2022, background): “Several cytokines and chemokines (miR-214 [60], IL-1 [61], α-SMA, integrin β-1), and signaling pathways (EGFR, Wnt/β-catenin, Hippo, TGF-β, and JAK/STAT cascades) reprogram normal fibroblasts into CAFs [62, 63].”
• Adipose tissue plasticity in health and disease (2022, background): “Interestingly, fibro-blasts with this gene-expression signature are present in nearly every tissue of the body (Buechler et al., 2021).”
• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “More recently, the MSCs/fibroblast atlases were constructed by integrating available single-cell transcriptomic data.(20) Based on the transcription profiles across tissues, two universal subtypes were identified as the primitive lineages to generate more specialized descendants in health and diseas”
• The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans (2021, background): “Studying particular cell types across organs, datasets, and species will yield new biological insights— as shown with fibroblasts (32).”