IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes
By Hai-hui Xue, P. Kovanen, C. Pise-Masison, M. Berg, Michael F. Radovich, J. Brady, W. Leonard. Proceedings of the National Academy of Sciences of the United States of America, 2002
184 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/1017d04ab9e024f45f60db917b13ad53d2b09621
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In Immunology
Citations in the corpus
- New insights into the regulation of T cells by γc family cytokines (2009, unknown): “IL-2, IL-7 and other pro-survival cytokines can transiently decrease the expression of IL-7Rα on T cell”
- GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells (2004, background): “In peripheral T cells, activation via the T cell receptor substantially downregulates IL-7Rα expressio”
- Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, unknown): “During infection, CD25 expression is initially high but then becomes heterogeneous; cells that downregulate CD25 early in infection receive a less prolonged or ‘‘intense’’ IL-2 signal, upregulate IL-7Ra and CD62L, and eventually become long-lived memory cells, whereas cells expressing higher numbers”
- IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “Because IL-7 is a known survival factor, IL-7Ra repression can serve to diminish survival signals, thereby potentially facilitating activation-induced cell death, a process that requires pre-exposure to IL-2, and/or the contraction phase that follows T-cell expansion during a viral response [34 ].”